Insulin and C-peptide response to an oral glucose load have been assessed in 10 cirrhotic, 5 non-obese maturity onset diabetic, and 5 normal subjects.
I. In normal subject, blood glucose levels at fasting state, 1-hour, and 2-hour after glucose load were 78.4±2.97 mg/100,ml, 102.4±6.92 mg/100 ml, and 81.0±5.70 mg/100 ml, respectively. Blood insulin levels were 19.2±0.96uU/ml, 85.2±10.34 uU/ml, and 352±3.55 uU/ml, and C-peptide levels were 1.83±0. 10 ng/ml, 8.02±0.25 ng/ml. and 3.94±0.28 ng/ml, respectively.
II. In the group of diabetes, blood glucose levels were 160.0±21.73 mg/100 ml 275.0±32.41 mg/100 ml, and 299.8±49. 15 mg/300 ml respectively. Insulin levels in the blood were 10.0±2.29 uU/ml, 20.6± 5.23´uU/ml, and 29.0±0.40 uU/ml, and C-peptide levels were 0.84±0.44 ng/ml, 2.93±0.68 ng/ml, and 3.04±0.88 ng/ml respectively.
1. In subject of liver cirrhosis, blood glucose levels were 72.6±4.31 mg/100 ml, 172.6±17.23 mg/ 100 mi, and 160.7-±5.42mg/100ml respectively. Blood insulin levels were 20.8±1.88 uU/ml, 109.9±27.76 uU/ml, and 157.0±41.56 uU/ml respectively; C-peptide levels Were 0.88±0.21ng/ml, 3.88±0.46ng/ml, and 5.64±-1.06ng/ml, respectively.
The above result is suggested that in differentiation between maturity onset diabetes and hepatic diabetes, C-peptide measurement after oral glucose load could be helpful.
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